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KMID : 0352720070310020079
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Journal of Ginseng Research
2007 Volume.31 No. 2 p.79 ~ p.85
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Effects of Compound K on Insulin Secretion and Carbohydrate Metabolism
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Choi Yun-Sook
Han Ki-Chul
Han Eun-Jung
Park Keum-Ju
Sung Jong-Hwan
Chung Sung-Hyun
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Abstract
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Compound K (CK) is a final metabolite of panaxadiol ginsenosides. Although panax ginseng is known to have anti-diabetic activity, the active ingredient is not yet fully identified. Therefore, it would be interesting to know whether and how CK has an anti-diabetic activity. First, insulin secretion-stimulating activity of CK was examined using RIN-m5F cell line and primary cultured islets. CK enhanced the insulin secretion in a concentration dependent manner. This effect, however, was almost completely abolished in the presence of diazoxide, K? channel opener, indicating that the insulin secretion-stimulating activity of CK is presumably due to blockade of ATP sensitive K? channel. In addition, effects of CK on gene expressions of hepatic enzymes (phosphoenolpyruvate carboxykinase[PEPCK], glucose-6-phosphatase[G6Pase]) and on adipocyte differentiation in H4IIE and 3T3-L1 cells, respectively, were examined. CK suppressed the induction of PEPCK and G6Pase mRNA expressions under the dexamethasone/cAMP stimulation condition. CK also reduced the PPAR-γ mRNA expression and triglyceride accumulation in a dose dependent manner as compared to the control. The present study suggests that CK deserves to examine whether it shows an anti-diabetic activity in animal and human studies.
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KEYWORD
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compound K, anti-diabetic activity, insulin secretion, ATP sensitive K? channel, PEPCK, G6Pase, PPAR-γ
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